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If prior therapy consists of metformin 2,000 mg/day, start with 2 mg/1,000 mg and administer 1 tablet twice daily. I was taking Amaryl once a day and metformin twice a day, plus Diovan for blood pressure. The following information includes only the average doses of metformin and rosiglitazone. Use of metformin and rosiglitazone can increase the risk of serious side effects in these patients. , x-rays, CT scans, and MRIs) that use intravenous contrast media—Use of metformin and rosiglitazone should be discontinued before you have one of these procedures. Furthermore, discontinuation or dose reduction of rosiglitazone maleate/metformin hydrochloride must be considered.

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